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However, we did not find any significant differences between the benfotiamine and placebo group. The difference between the current study and former studies that reported a positive effect of benfotiamine may be related to differences in the investigated populations. Symptomatic polyneuropathy was not an inclusion criterion in the current study (symptom scoring was not meaningful because most patients were asymptomatic). However, because the former studies did not report neurophysiologic function, we cannot exclude that the reported effect was related to symptom reduction and not improved nerve function per se.
Special Precautions and Warnings
Birth control pills used for contraception and hormone replacement therapies (HRT), like progesterone and estrogen, are examples. Women who have undergone a full hysterectomy, for example, require ongoing HRT after surgery. We would like to thank Maha Abdulmohsen Alenzi, a dietician from the Armed Forces Hospital in Dhahran, Saudi Arabia who provided insight and expertise that greatly assisted the research. Benfotiamine supplements are widely available online and in stores specializing in supplements.
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High doses of vitamin A and medications derived from it can cause hair loss. Here are some of the types of medications that can cause hair loss as a side effect. Some forms of hair loss are temporary, while others, like pattern baldness, are permanent. Always consult a health care professional prior to taking benfotiamine or any other dietary supplement.
Editorial Advisory Board Member, Harvard Health Publishing
The Reasons Why You Can Get a Vitamin B Rash, Hives or Flush - Livestrong
The Reasons Why You Can Get a Vitamin B Rash, Hives or Flush.
Posted: Sat, 26 Sep 2015 15:14:46 GMT [source]
Furthermore, NADPH oxidase has been reported to play a critically important role in ISO-induced ROS [10,27]. Benfotiamine pre- and post-treatments showed normalization and complete protection against the elevation of NADPH oxidase activity. Benfotiamine, a specific NADPH oxidase inhibitor, was found to not only inhibit the activity of NADPH oxidase but also reduce the expression of the enzyme and directly scavenge superoxide radical anions [28]. Studies on the role of iron in AA have shown a discrepancy in the results between females and males. There is a need for placebo-controlled clinical trials evaluating iron supplementation in the treatment of AA. Most studies on zinc have revealed lower serum levels in AA patients than in controls.
Thiamine is a water-soluble essential micronutrient that cannot be synthesized endogenously, so dietary intake is the only source of this vitamin. Foods rich in thiamine include meats such as pork and beef, fish, whole grains, wheat germ, eggs, legumes, and nuts [26]. In contrast, certain foods such as coffee, tea, raw fish and shellfish contain thiaminases - enzymes that destroy thiamine. Unlike humans, microbes such as Salmonella enterica and Escherichia coli are capable of synthesizing thiamine de novo [27]. Because thiamine is a hydrophilic vitamin, it cannot pass freely across cell membranes and relies on thiamine transporters to enter the cell.
Also at risk for vitamin B1 deficiency are individuals who have lost weight or have had gastric bypass surgery, are pregnant or lactating, have hyperthyroidism or HIV/AIDS, or are taking diuretic or fluid-loss-promoting medications. Chewing betel/areca nuts regularly and frequently consuming raw fish or shellfish can also contribute to thiamine deficiency. Thiamine, the first vitamin to be identified, is a B vitamin found in foods such as nuts, meats, whole grains, and legumes. Also called vitamin B1, thiamine is an essential nutrient for proper cellular growth and function. Scientists are studying benfotiamine to determine if it could be helpful in conditions where B1 deficiency either causes or exacerbates symptoms of the disease. The authors of a few studies suggest that the levels of folate or vitamin B12 might modify the progression of AA, but data are still too limited to recommend screening or supplementation of B vitamins.
Benfotiamine: Uses, Benefits, Side Effects, Dosage - Verywell Health
Benfotiamine: Uses, Benefits, Side Effects, Dosage.
Posted: Tue, 21 Feb 2023 08:00:00 GMT [source]
Biotin Side Effects
Selenium deficiency occurs in low-birth-weight infants and in patients requiring total parenteral nutrition (TPN). It can also occur among people living in a location where the soil lacks selenium [34]. It is essential to carefully read a supplement's ingredients list and nutrition facts panel to learn which ingredients are in the product and how much of each ingredient is included. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. A review of six trials that studied the effect of benfotiamine on diabetic nerve pain was inconclusive.
Benfotiamine is a dietary supplement that is converted in the body to thiamine (vitamin B1). Thiamine helps your body turn nutrients into energy and is essential for brain function. Some people use benfotiamine to raise thiamine levels because it is considered to be highly bioavailable. This means that it reaches the bloodstream quickly and produces high levels of thiamine in the body. According to the American Academy of Dermatology, it’s completely normal to shed anywhere between 50 to 100 strands of hair per day. However, if you’ve noticed more strands falling out of your head than normal, you may be experiencing alopecia, the medical term for hair loss.
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Hair transplant, or restoration surgery, can make the most of the hair you have left. The National Institute on Aging is funding a small pilot study to look at whether benfotiamine could slow the decline of mental skills, like thinking and remembering, in people with mild Alzheimer’s. If you’re experiencing pattern baldness as a result of medication, some treatments like Rogaine (men and women), Propecia (men), and dutasteride (men) may be right for you. Hormone therapies can trigger hormone imbalances in women, causing hair loss — and potentially causing permanent female pattern baldness. Gout medications like allopurinol (Zyloprim and Lopurin) have been reported to cause hair loss. Some statin drugs like simvastatin (Zocor) and (atorvastatin) Lipitor have been reported to cause hair loss.
The Food and Drug Administration has approved a low-level laser device as a treatment for hereditary hair loss in men and women. Scientists are studying it to see if it might help conditions like diabetes-related nerve damage, Alzheimer’s disease, and alcohol dependence. In vitro studies suggest that benfotiamine may halt leukaemia by a mechanism termed paraptosis cell death. Paraptosis is a type of programmed cell death which involves cytoplasmic vacuole formation.
Studies show that supplementing the diet with low levels of vitamin D can improve symptoms of these diseases. If a patient with AGA or TE has low iron levels (more commonly seen in females), supplementation is also recommended. These iron-deficient patients should also ensure their vitamin C intake is appropriate. At the present time there is insufficient data to recommend zinc, riboflavin, folic acid, or vitamin B12 supplementation in cases of deficiency. Neither vitamin E or biotin supplementation are supported by the literature for treating AGA or TE; in addition, biotin supplementation can also lead to dangerous false laboratory results. Studies show that too much vitamin A can contribute to hair loss, as can too much selenium, although more studies are needed to establish the latter relationship.
So, in this context, vitamin B1 is probably not something that most AGA patients need to worry about. It also doesn’t mean we should warn people that hair loss is a side effect of a water deficiency. Means (95% CIs) are given for continuous normally distributed data and medians (quartiles) for highly skewed data. Differences between groups over 24 months were tested by two independent sample t tests or Mann-Whitney U tests. Power calculations based on our primary end point (peroneal NCV) indicated that at least 55 patients would be required (standardized difference 0.75; 80% power, 5% significance level).
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